The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis
نویسندگان
چکیده
A 65-year-old man, with a history of hypertension and hyperlipidemia, presented with intractable lower back pain, shortness of breath, and decreasing urine output at the emergency room and was admitted after he was found to have elevated creatinine kinase levels of greater than 160,000 U/L. We discontinued all his home medications, which included atorvastatin and amlodipine. We trended his creatine phosphokinase (CPK) level daily and noticed it decreasing significantly off these meds. We hydrated him with normal saline and monitored his kidney functions. By the time he was ready for discharge, his CPK levels were back to normal. This case report summarizes the drug-drug interactions of atorvastatin and amlodipine.
منابع مشابه
Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor
Atorvastatin and ticagrelor combination is a widely accepted therapy for secondary prevention of ischaemic heart disease. However, rhabdomyolysis is a well-known rare side effect of statins which should be considered when treatments are combined with cytochrome P450 3A4 enzyme inhibitors. We report a case of atorvastatin and ticagrelor associated severe rhabdomyolysis that progressed to multior...
متن کاملA Quick and Sensitive Liquid Chromatography-Tandem Mass Spectrometry (LC-MS) Method for the Evaluation of Two Formulations of Amlodipine and Atorvastatin in Healthy Male Volunteers
An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participants randomly assigned in a 1:1 ratio to be given one tablet of the test or reference formulation, followed by a 2-week washout period and administration of the exchange formulation. A quick and susceptible Liquid Chromatography–tandem Mass Spectro...
متن کاملHeart attack or rhabdomyolysis?
Statins are commonly used drugs in the treatment of hyperlipidemia (HL), despite some undesirable side effects. These range from mild symptoms such as myopathy, muscle weakness and myalgia to severe muscle weakness associated with chronic myopathy and acute renal failure (ARF) as a result of rhabdomyolysis. The most serious and deadly side effect of statins is rhabdomyolysis. The case presente...
متن کاملRisk factors Related to Rhabdomyolysis in Thai Statin Users: A Case-control Study
Previous studies on statin have revealed that increasing age, renal insufficiency, and concomitant medications were associated with rhabdomyolysis. However, there is a lack of analysis on the magnitude of such association in the Asia-Pacific region. The objectives of this study were to identify risk factors of statin-associated rhabdomyolysis in Thai patients and to evaluate the magnitude of as...
متن کاملBioavailability of amlodipine besylate/atorvastatin calcium combination tablet.
The bioequivalence of combination tablets containing amlodipine besylate/atorvastatin calcium with coadministered matching doses of amlodipine besylate and atorvastatin calcium tablets was investigated in randomized, 2-way crossover studies in healthy volunteers (N = 126). Subjects received a single dose of the amlodipine/atorvastatin tablet or coadministered matching doses of amlodipine and at...
متن کامل